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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue

doi: 10.1126/science.279.5357.1718

By combining them, researchers can investigate a broader range of biological mechanisms while maintaining consistency across experimental designs

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-Matthew Obal, PA-C As an internal medicine PA, I often see patients who are suffering from tendinitis and joint pain